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Recently, ATG43 is identified as another mitophagy-specific receptor, which is localized on the mitochondrial outer membrane and binds to ATG8 ( In mammals, the regulation of mitophagy appears to be more complex, both ubiquitin-mediated and receptor-mediated pathways have been described in response to mitophagy

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For all of these reasons, it is critical to consult with your healthcare physician on a frequent basis to determine how TN is impacting you and whether your treatment plan is effective